We are organizing AIRDEGEN 2021 Workshop:
Despite decades of neurodegenerative disease (ND) research, the real molecular pathophysiology of the disease is still poorly understood, and treatments remain inadequate. Remarkably little attention is paid to the involvement of environmental factors, which are known from epidemiological studies to strongly impact ND development. Air pollution, a massive public health issue known to pose a major threat to human health, is an important, ever-increasing global concern. A growing body of evidence from epidemiological and controlled animal studies shows that exposure to air pollutants also impairs the brain. Furthermore, living in highly polluted areas is associated with exacerbated cognitive dysfunction and ND. Many questions remain unanswered as mechanistic information on air pollutant effects on the brain is scarce. Importantly, biomarkers for air pollution and ND risk prediction do not currently exist, thus hindering the identification and stratification of individuals at risk for harmful air pollution effects.We are organizing MODIMO 2021 Workshop:
Multi-omics analysis aims at extracting previously uncovered biological knowledge by integrating information across multiple single-omic sources. Past approaches have focused on the simultaneous analysis of a small number of omic data sets. Current challenges face the problem of integrating multiple omic sources into a unified complex model, or of combining already available tools for two-by-two omics analyses and merging their outcomes. By doing so and leveraging integrated system-level knowledge, multi-omic approaches ought to enable the development of better qualitative and quantitative models for descriptive and predictive analyses. To move this area forward, new statistical and algorithmic frameworks are needed, for example for generalizing classical graph theory results to heterogeneous networks, and applying them to diverse problems such as drug repurposing or understanding the immune response to infections. Thus, in short, this workshop aims at investigating novel methodologies for providing crucial insights into multi-omics data management, integration, and analysis in order to enable biological discoveries. Read more.We are presenting one poster "Variant and haplotype aware motif scanning on genome variation graphs" at RECOMB 2021:
RECOMB 2021 is the 25th edition of a series of algorithmic computational biology conferences bridging the areas of computational, mathematical, statistical and biological sciences. The conference features keynote talks by preeminent scientists in life sciences, presentations of ground breaking research in computational biology, selected over the course of a highly-rigorous peer-review process, and poster sessions on the latest research progress. Read more.Join the virtual conference to talk with Manuel about his work! In a hurry? Check out the short video presention below!
We are presenting a tutorial on Imaging Genetics at ICHI 2021 Conference:
Imaging genetics is an emerging longitudinal research field bridging genetic insights to complex neurological diseases, exploiting quantitative brain imaging phenotypes. Imaging genetics primarly focus on identifying and characterizing how genic expression and genomic variation affect neuroanatomical and neurophysiological traits, by exploiting brain images information. Until now, have been proposed several imaging genetics methods to investigate and improve our knowledge on different complex diseases, such as Alzheimer's disease, but only few works focused on Parkinson's Disease (PD). Using PD as study case, our lab members Guglielmo Cerri, Rosalba Giugno and Manuel Tognon will showcase a tutorial on imaging genetics during ICHI 2021, guiding the attendents through the different steps of the analysis. Moreover, they will also present an innovative multi-view imaging genetics workflow, which exploits the advantages of existing methods to analyze heterogenous data, such as genotyping, transcriptomic, and neuromorphological and functional brain images. During the tuorial will be presented the main aspects of imaging genetics analyses, moving from classical quality control to more techinical steps of the proposed method, such as GWAS, differential expression analysis and functional annotation. The talk will take place on August 11th 2021 during ICHI 2021 (held online). Read more.We are presenting three abstracts at BITS 2021 Conference:
BITS conference highlights keynote talks by excellent scientists in bioinformatics and its applications, presentations of state-of-the-art research in computational biology, and poster sessions on the latest research progress. Join the virtual conference to listen to 3 oral presentations by Manuel, Vincenzo, and Giovanni & Eva. Read more.Structural variants (SVs) are large genomic alterations (> 50 bp). These
genomic variants are typically classified as deletions, duplications,
insertions, inversions, and translocations describig different combinations
of DNA gains, losses, or rearrangements.
What the student will do?
- Learn how to work and structure platforms based on federated data.
- Co-develop an efficient user interface that will allow clinicians to
visualize, filter and analyze SVs derived from sequencing data.
If interested write an email to prof. Rosalba Giugno (rosalba.giugno@univr.it)
or to Benjamin Huremagic ( benjamin.huremagic@kuleuven.be).
The candidate will study interactions between air pollution and cognitive decline
in the context of Horizon 2020 - TUBE European project.
If intersted write an email to prof. Rosalba Giugno (rosalba.giugno@univr.it).
The candidate will study interactions between air pollution and cognitive decline
in the context of Horizon 2020 - ADAIR European project.
If intersted write an email to prof. Rosalba Giugno (rosalba.giugno@univr.it).